Chapter

Loveless and wasp-venom immunotherapy

Anthony Dubois

in Landmark Papers in Allergy

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199651559
Published online April 2013 | e-ISBN: 9780191754241 | DOI: http://dx.doi.org/10.1093/med/9780199651559.003.0028

Series: Landmark Papers

Loveless and wasp-venom immunotherapy

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We have reported that the patient with extreme allergy toward wasp stings can be protected for months by a one-visit, 2½-hr course that conveys 6 sacsful of wasp venom in about six divided doses by the endermal route. Although this probably represents the ultimate abbreviation of effective immunization with fluid venom, experience with emulsified allergen in hay fever has suggested that the entire dose of venom might be tolerated in a single subcutaneous injection if incorporated in mineral oil. At the same time, it seemed likely that an already low incidence of adverse reactions to fluid venom might be further reduced, whereas the resulting immunity might be prolonged. Accordingly, nine polistes-allergic persons were given trial repositories of polistes venom during 1960 and 1961, two other individuals with the same allergy being assigned to fluid venom to provide concurrent data for comparisons.

Chapter.  1140 words. 

Subjects: Public Health and Epidemiology ; Immunology ; Respiratory Medicine and Pulmonology

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