Chapter

RAST: Iconic test for allergic sensitization

Shuaib Nasser

in Landmark Papers in Allergy

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199651559
Published online April 2013 | e-ISBN: 9780191754241 | DOI: http://dx.doi.org/10.1093/med/9780199651559.003.0032

Series: Landmark Papers

RAST: Iconic test for allergic sensitization

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  • Public Health and Epidemiology
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An in-vitro method, called the radioallergosorbent test, has been developed for the detection of allergen-specific antibodies of a new immunoglobulin class, provisionally called IgND. Antibodies to 14 different allergens were detected in sera of allergic patients. A 96% agreement was obtained between results from provocation tests and the in-vitro test for allergy. The results strongly support the hypothesis that reagins belong to the immunoglobulin class IgND. The method described might become of great importance for the clinical diagnosis of hypersensitivity to various allergens.

Chapter.  1102 words. 

Subjects: Public Health and Epidemiology ; Immunology ; Respiratory Medicine and Pulmonology

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