Chapter

The dawn of molecular allergology

Hannah Gould

in Landmark Papers in Allergy

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199651559
Published online February 2013 | e-ISBN: 9780191754241 | DOI: http://dx.doi.org/10.1093/med/9780199651559.003.0037

Series: Landmark Papers

The dawn of molecular allergology

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Studies of the nature of the antibodies associated with isologous skin sensitizing activity have indicated the presence of a previously unrecognized immunoglobulin in human serum. The immunoglobulin was identified by virtue of specific antigenic determinants. Independently, a protein with similar antigen characteristics was identified both in the serum of a patient with multiple myeloma and in normal serum. It is proposed that the normal protein and antigenically related myeloma proteins shall be designated IgE or γ‎E, and the heavy polypeptide chains of these molecules be designated ε‎ (epsilon)-chains, in accordance with Nomenclature for Human Immunoglobulins. This replaces the previous usage of γ‎E-globulin and IgND.

Chapter.  1183 words. 

Subjects: Public Health and Epidemiology ; Immunology ; Respiratory Medicine and Pulmonology

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