Chapter

Immunotherapy can change the natural history of respiratory allergy

Walter Canonica

in Landmark Papers in Allergy

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199651559
Published online April 2013 | e-ISBN: 9780191754241 | DOI: http://dx.doi.org/10.1093/med/9780199651559.003.0038

Series: Landmark Papers

Immunotherapy can change the natural history of respiratory allergy

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  • Public Health and Epidemiology
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Johnstone and Dutton report the results of a 14-year prospective study begun in August 1953. They conducted a prospective controlled study of 210 children with perennial bronchial asthma; half the children received hyposensitization therapy and half placebo control treatment. In 1967, when the children were aged 16, 130 were still under observation; 22% of the placebo-treated children were free of asthma compared to 72% of the treated children. The chance of a child outgrowing asthma was not significantly influenced by the child’s sex, age of onset, or severity of symptoms. A previous history of hay fever significantly increased the likelihood of a child’s asthma persisting into adolescence. The authors suggest that their findings indicate that young children with even mild asthma, particularly those also with hay fever, should be considered for hyposensitization therapy, as they cannot be expected to outgrow the illness.

Chapter.  1033 words. 

Subjects: Public Health and Epidemiology ; Immunology ; Respiratory Medicine and Pulmonology

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