Chapter

Delayed hypersensitivity to pollen allergens

Tom Platts-Mills

in Landmark Papers in Allergy

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199651559
Published online April 2013 | e-ISBN: 9780191754241 | DOI: http://dx.doi.org/10.1093/med/9780199651559.003.0041

Series: Landmark Papers

Delayed hypersensitivity to pollen allergens

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  • Public Health and Epidemiology
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  • Respiratory Medicine and Pulmonology

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Pollen-induced lymphocyte transformation in hay-fever subjects with clinical immediate hypersensitivity reflects the presence of a sensitised thymus-dependent cell population, which also gives rise to positive macrophage and leucocyte migration-inhibition tests in vitro and delayed-type skin tests in vivo. It is postulated that the thymus-dependent (T-) lymphocytes cooperate in the production of IgE antibody by B-lymphocytes of the plasma-cell series. Lymphocyte transformation per se should still be regarded as a manifestation of cell-mediated (delayed) hypersensitivity in vitro, whatever the apparent clinical correlations may be.

Chapter.  1325 words. 

Subjects: Public Health and Epidemiology ; Immunology ; Respiratory Medicine and Pulmonology

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