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Once more unto the breach: the role of the damaged bronchial epithelium in asthma

Karl Staples and Ratko Djukanovic

in Landmark Papers in Allergy

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199651559
Published online April 2013 | e-ISBN: 9780191754241 | DOI: http://dx.doi.org/10.1093/med/9780199651559.003.0056

Series: Landmark Papers

Once more unto the breach: the role of the damaged bronchial epithelium in asthma

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Addressing the hypothesis that epithelial damage is related to bronchial hyperreactivity, Laitinen et al. measured bronchial reactivity to inhaled histamine and took biopsies from three levels of the airway mucosa of eight adult patients with mild to severe asthma and one control subject, preparing electron micrographs from the specimens. The results showed that asthma patients can have profound airway epithelium destruction at all levels of the airway, with ciliated cells the most destroyed cell type. The authors suggest that epithelial damage is caused by asthma itself rather than medication.

Chapter.  1211 words. 

Subjects: Public Health and Epidemiology ; Immunology ; Respiratory Medicine and Pulmonology

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