Chapter

Clinical physiology of testosterone

T. Hugh Jones

in Testosterone Deficiency in Men

Second edition

Published on behalf of Oxford University Press

Published in print December 2012 | ISBN: 9780199651672
Published online December 2012 | e-ISBN: 9780191742958 | DOI: http://dx.doi.org/10.1093/med/9780199651672.003.0002

Series: Oxford Endocrinology Library

Clinical physiology of testosterone

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Adequate tissue androgenization is dependent on a balance of testosterone synthesis and breakdown, the fraction of biologically active testosterone in the circulation and available to the tissues, androgen receptor sensitivity, and non-genomic effects. Circulating testosterone is divided into three major fractions: free, albumin-bound, and SHBG-bound. The free plus the albumin-bound testosterone constitutes the bioavailable testosterone. The CAG androgen receptor polymorphism affects sensitivity of the receptor and has clinical consequences. Testosterone has actions independent of the classical androgen receptor, which mediate effects through non-genomic mechanisms. Testosterone levels are affected adversely by age and obesity.

Chapter.  3934 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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