Primary hypogonadism

Arif Hamda and Pierre-Marc Bouloux

in Testosterone Deficiency in Men

Second edition

Published on behalf of Oxford University Press

Published in print December 2012 | ISBN: 9780199651672
Published online December 2012 | e-ISBN: 9780191742958 | DOI:

Series: Oxford Endocrinology Library

Primary hypogonadism

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The majority of cases of primary hypogonadism are associated with failure of testosterone production and spermatogenesis. Klinefelter’s syndrome is the commonest cause of primary hypogonadism, occurring in approximately 1 in 500 male births. Congenital causes of hypogonadism are associated with cryptorchidism – failure of one or both testicles to descend. Maldescent of the testis increases the risk of subsequent development of testicular cancer by 10%. Congenital causes of primary hypogonadism are associated with tall stature due to failure of epiphyseal closure and eunuchoid body shape.

Chapter.  3786 words. 

Subjects: Endocrinology and Diabetes

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