Chapter

The prostate and other safety issues

Hermann M. Behre

in Testosterone Deficiency in Men

Second edition

Published on behalf of Oxford University Press

Published in print December 2012 | ISBN: 9780199651672
Published online December 2012 | e-ISBN: 9780191742958 | DOI: http://dx.doi.org/10.1093/med/9780199651672.003.0008

Series: Oxford Endocrinology Library

The prostate and other safety issues

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Conditions in which testosterone administration is associated with a high risk of adverse outcome have to be ruled out carefully before initiating therapy. Hypogonadal patients on testosterone substitution therapy should be monitored for potential adverse side effects on a regular basis. Testosterone therapy stimulates prostate growth in patients with hypogonadism, but only to that comparable with age-matched controls. Patients with lower urinary tract symptoms before as well as during testosterone therapy should obtain a urological evaluation. Testosterone therapy is contraindicated in men with prostate carcinoma. However, there is no convincing evidence that testosterone substitution therapy induces prostate carcinoma. Before long-term, large prospective studies on the effects of testosterone therapy on prostate function are available, close monitoring of prostate function, including digital rectal examination and measurement of prostate-specific antigen, is recommended. Erythropoiesis is stimulated by testosterone therapy. In patients with haematocrit elevated to the supraphysiological range, dose adjustments or cessation of therapy might be indicated. In the case of formulation-specific adverse side effects, patients might be switched to another testosterone preparation.

Chapter.  3092 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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