Testosterone and erectile dysfunction

Ahmed I. El-Sakka, Aksam A. Yassin and Farid Saad

in Testosterone Deficiency in Men

Second edition

Published on behalf of Oxford University Press

Published in print December 2012 | ISBN: 9780199651672
Published online December 2012 | e-ISBN: 9780191742958 | DOI:

Series: Oxford Endocrinology Library

Testosterone and erectile dysfunction

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Severe hypogonadism in men usually results in loss of libido and potency which can be restored by androgen administration. The original insights into the mechanisms of action of androgens on sexual function indicated that androgens mainly exert effects on libido. But testosterone appears to have profound effects on tissues of the penis involved in the mechanism of erection. Testosterone deficiency impairs the anatomical and physiological/biochemical substrate of erectile capacity, reversible upon androgen treatment. Androgen deprivation in humans results in low sexual desire or libido, impaired erectile function, and alteration in penile histological structures and size. The administration of PDE-5 inhibitors is not always sufficient to restore erectile potency and administration of testosterone improves the therapeutic response to PDE-5 inhibitors considerably. Furthermore, low levels of testosterone are closely related to manifestations of other aetiological factors in erectile dysfunction, such as atherosclerotic disease and diabetes mellitus.

Chapter.  2723 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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