Chapter

Obesity, metabolic syndrome, and diabetes

T. Hugh Jones

in Testosterone Deficiency in Men

Second edition

Published on behalf of Oxford University Press

Published in print December 2012 | ISBN: 9780199651672
Published online December 2012 | e-ISBN: 9780191742958 | DOI: http://dx.doi.org/10.1093/med/9780199651672.003.0011

Series: Oxford Endocrinology Library

Obesity, metabolic syndrome, and diabetes

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Low testosterone and SHBG levels in healthy men are independent risk factors for the subsequent development of the metabolic syndrome and type 2 diabetes. High prevalence of hypogonadism in men with the metabolic syndrome and type 2 diabetes. Low testosterone levels are associated with insulin resistance. The hypogonadal–obesity–adipocytokine cycle hypothesis defines the stimulatory effect of obesity on testosterone metabolism and the impaired ability of the hypothalamic–pituitary–testicular axis to respond. The diagnosis of hypogonadism in men with the metabolic syndrome and diabetes requires rigorous assessment and the decision to treat should be made by an experienced clinician. Short-term studies have demonstrated that testosterone replacement improves insulin resistance, glycaemic control, and visceral adiposity.

Chapter.  5354 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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