Chapter

The role of androgens in osteoporosis and frailty

Karen Choong and Shalender Bhasin

in Testosterone Deficiency in Men

Second edition

Published on behalf of Oxford University Press

Published in print December 2012 | ISBN: 9780199651672
Published online December 2012 | e-ISBN: 9780191742958 | DOI: http://dx.doi.org/10.1093/med/9780199651672.003.0014

Series: Oxford Endocrinology Library

The role of androgens in osteoporosis and frailty

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Ageing is associated with declines in skeletal muscle mass, muscle strength and power, physical function, and bone mass and quality; these impairments contribute to increased risk of falls, disability, and fractures. In epidemiological studies, low testosterone levels are associated with lower skeletal muscle mass, muscle strength, physical function, and bone mineral density and higher risk of functional limitations, fractures, and mortality. Testosterone therapy in older men with low and low-normal testosterone levels improves lean body mass and grip strength. However, the effects of testosterone on physical function and health-related outcomes in older men with functional limitations need further investigation. Testosterone promotes the differentiation of mesenchymal multipotent stem cells into the myogenic lineage by androgen receptor-mediated mechanisms. The long-term risks of testosterone administration on prostate and cardiovascular outcomes are unknown. Selective androgen receptor modulators that selectively increase muscle mass without affecting the prostate would be attractive as function-promoting therapies.

Chapter.  3961 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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