Chapter

The Biochemical, Haematological, Histological, Immunological, and Genetic Investigation of Epilepsy

Simon Shorvon

in Oxford Textbook of Epilepsy and Epileptic Seizures

Published on behalf of Oxford University Press

Published in print December 2012 | ISBN: 9780199659043
Published online December 2012 | e-ISBN: 9780191751363 | DOI: http://dx.doi.org/10.1093/med/9780199659043.003.0011

Series: Oxford Textbook of

The Biochemical, Haematological, Histological, Immunological, and Genetic Investigation of Epilepsy

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Epilepsy can be the result of many neurological conditions. The routine investigation of epilepsy is relatively straightforward and involves a relatively simple battery of imaging, neurophysiological and laboratory tests. However, if the cause remains obscure despite these screening tests, there are further investigations which can be carried out to identify the less common underlying aetiologies. In this chapter these investigations are listed and include: biochemical investigations of urine, CSF and blood, haematological investigation, histological, immunological and genetic tests. It must be emphasized that a detailed clinical examination and history, including the family history, are as important in assessing causation as any test. The utility and correct interpretation of many of these complex investigations depends on the clinical context. The chapter ends with examples of the investigations used in the clinical investigation of urea cycle defects, peroxysmal and lysosomal storage disorders.

Chapter.  4529 words. 

Subjects: Neurology

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