Chapter

Pathogenesis

Raymond W. Lam

in Depression

Second edition

Published on behalf of Oxford University Press

ISBN: 9780199692736
Published online February 2012 | e-ISBN: 9780199607013 | DOI: http://dx.doi.org/10.1093/med/9780199692736.003.0003

Series: Oxford Psychiatry Library

Pathogenesis

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• There are likely multiple processes to explain the etiology and pathophysiology of depression, with involvement of biological, psychological and social factors. • Circadian rhythmicity, stressful life events and stress reactivity can modify genetic and biological processes (gene-environment interactions) to contribute to depression. • Endophenotypes, or genetic expressions of neural systems involved in depression, will be important in the study of the pathogenesis of depression and the development of novel treatments.

Chapter.  3046 words.  Illustrated.

Subjects: Psychiatry

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