Chapter

Obsessive–compulsive disorder

Joseph Zohar, Leah Fostick and Elizabeth Juven-Wetzler

in New Oxford Textbook of Psychiatry

Second edition

Published on behalf of Oxford University Press

Published in print February 2012 | ISBN: 9780199696758
Published online October 2012 | e-ISBN: 9780191743221 | DOI: http://dx.doi.org/10.1093/med/9780199696758.003.0100
Obsessive–compulsive disorder

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The efficacy of the SRIs for OCD, together with the lack of efficacy of adrenergic antidepressants, has suggested that serotonin is involved in the pathophysiology of OCD. This relationship was validated by research on serotonergic markers in OCD and by the challenge paradigm. Which type of serotonergic receptor is involved in the pathogenesis and/or the mechanism of action of anti-obsessional drugs, is still unclear. However, the possible role of 5HT1B has emerged. Further studies are crucial for elucidating the role of serotonin and other neurotransmitters (i.e. dopamine) in the pathophysiology and management of OCD.

Chapter.  7886 words. 

Subjects: Psychiatry

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