Chapter

Antiretroviral agents

Roger Finch, Peter Davey, Mark Wilcox and William Irving

in Antimicrobial Chemotherapy

Sixth edition

Published on behalf of Oxford University Press

Published in print January 2012 | ISBN: 9780199697656
Published online November 2013 | e-ISBN: 9780191770821 | DOI: http://dx.doi.org/10.1093/med/9780199697656.003.0047
Antiretroviral agents

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Chapter 5 discusses antiretroviral drugs, which are commonly formulated as combination products in the hope of suppressingthe development of resistance, to simplify the often complex dosage regimens that are required for effective therapy and, in some cases, to exploit possible synergistic interactions. It also discusses how the frequent occurrence of toxic interactions between various antiretroviral compounds demands careful selection of such drug permutations. It covers reverse transcriptase inhibitors (RTIs), non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs), protease inhibitors, fusion inhibitors, CCR5 binding inhibitors, integrase inhibitors, and resistance to anti-HIV drugs.

Chapter.  2709 words.  Illustrated.

Subjects: Pharmacology ; Infectious Diseases ; Medical Microbiology and Virology

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