Lambert-Eaton Myasthenia Syndrome

Aaron E. Miller and Teresa M. DeAngelis

in Neuroimmunology

Published on behalf of Oxford University Press

Published in print December 2011 | ISBN: 9780199732920
Published online April 2013 | e-ISBN: 9780199322862 | DOI:

Series: What Do I Do Now

Lambert-Eaton Myasthenia Syndrome

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Lambert-Eaton myasthenia syndrome (LEMS) is an autoimmune-mediated disorder of the neuromuscular junction, which involves autoantibodies to voltage-gated calcium channels on the presynaptic membrane. In this chapter, we discuss the characteristic clinical features of LEMS, its electrophysiological distinction from MG, as well as its paraneoplastic presentation. We also review the immunotherapeutic management options in cases with severe weakness and those refractory to tumor removal.

Chapter.  1214 words. 

Subjects: Neurology

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