Chapter

The Immunopathogenesis of Myasthenia Gravis

Reinhard Hohlfeld, Hartmut Wekerle and Alexander Marx

in Myasthenia Gravis and Myasthenic Disorders

Second edition

Published on behalf of © 2012 by Mayo Foundation for Medical Education and Research

Published in print March 2012 | ISBN: 9780199738670
Published online April 2013 | e-ISBN: 9780199322848 | DOI: http://dx.doi.org/10.1093/med/9780199738670.003.0003

Series: Contemporary Neurology Series

The Immunopathogenesis of Myasthenia Gravis

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The discovery of the autoimmune origin of myasthenia gravis (MG) in the 1970s and the realization that the disease represents an autoimmune response to a well-characterized autoantigen, the acetylcholine receptor (AChR), had two major consequences. First, it paved the way for dissecting the mechanism of the autoimmune response in MG; second, it established MG as a disease of humans in which general principles of autoimmunity can be investigated. Central to the autoimmune response in MG are the role of the thymus gland and the manner in which B and T cells participate in it.

Chapter.  17257 words.  Illustrated.

Subjects: Neurology

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