Chapter

Natural History of Myasthenia Gravis

Vladimir Luchanok and Henry J. Kaminski

in Myasthenia Gravis and Myasthenic Disorders

Second edition

Published on behalf of © 2012 by Mayo Foundation for Medical Education and Research

Published in print March 2012 | ISBN: 9780199738670
Published online April 2013 | e-ISBN: 9780199322848 | DOI: http://dx.doi.org/10.1093/med/9780199738670.003.0004

Series: Contemporary Neurology Series

Natural History of Myasthenia Gravis

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MG manifests by fluctuating weakness and fatigability of any or all skeletal muscles with a predilection for the ocular muscles. The distribution, severity, and outcome of MG are determined mainly during the first one to three years after onset, suggesting that most injury to the postsynaptic surface of the skeletal muscle occurs during this time. In a significant minority of patients, the disease remains clinically localized to the ocular muscles; in the remaining patients it becomes generalized, usually within a year after onset. When the disease is localized to the ocular muscles for a year, there is a high likelihood that it will remain localized.

Chapter.  11212 words.  Illustrated.

Subjects: Neurology

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