Effects of Anti-ganglioside Antibodies at the Neuromuscular Junction

Jaap J. Plomp and Hugh J. Willison

in Myasthenia Gravis and Myasthenic Disorders

Second edition

Published on behalf of © 2012 by Mayo Foundation for Medical Education and Research

Published in print March 2012 | ISBN: 9780199738670
Published online April 2013 | e-ISBN: 9780199322848 | DOI:

Series: Contemporary Neurology Series

Effects of Anti-ganglioside Antibodies at the Neuromuscular Junction

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A wide variety of anatomical compartments within the peripheral nervous system (PNS) may potentially be affected in autoimmune neuropathy. PNS neurons extend very long myelinated and unmyelinated axons from their cell bodies localized within or near the spinal cord to their peripheral innervation sites. Accumulating evidence indicates that the neuromuscular junction (NMJ) can be one of the sites affected, in addition to more conventional sites such as the spinal roots. This chapter reviews recent animal experimental and human clinical electrophysiological evidence of a neuromuscular synaptopathy in anti-ganglioside antibody-mediated Guillain-Barré syndrome (GBS), against the background of the physiological roles of gangliosides in neurons and synapses.

Chapter.  6843 words.  Illustrated.

Subjects: Neurology

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