Chapter

The Next Decade of Research in the Basic Mechanisms of the Epilepsies

Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen and Antonio V. Delgado-Escueta

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0001

Series: Contemporary Neurology Series

The Next Decade of Research in the Basic Mechanisms of the Epilepsies

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In line with the view that understanding epileptogenesis is a critical research priority, investigators are seeking antiepileptogenic treatment strategies with the ambitious objective of preventing the onset of epilepsy or reversing it once it has become established. New animal models based on mutations of human genetic generalized epilepsies designed to investigate antiepileptogenic strategies are under development in order to study disease modification and cures. Successful approaches will likely have little similarity to drugs that are currently used to protect against seizures. Even with the recognition that symptomatic treatments for neurological disorders have been easier to come by than those that correct an underlying brain defect, there is nevertheless optimism that these new approaches will eventually lead to the prevention, repair, cure, and eradication of some forms of epilepsy.

Chapter.  3861 words.  Illustrated.

Subjects: Neurology

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