Chapter

Potassium Channels (Including KCNQ) and Epilepsy

Edward C. Cooper

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0005

Series: Contemporary Neurology Series

Potassium Channels (Including KCNQ) and Epilepsy

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This chapter aims to provide a perspective on the achievements and future potential of studies of potassium channels in epilepsy research. The thesis is that the understanding obtained from recent studies justifies continued investment in K+ channels by academic and industry-based researchers. We first reintroduce the K+ channels, highlighting progress that appears particularly relevant to epilepsy. Then, as an example, we provide a detailed account of one K+ channel subfamily, the KCNQ/Kv7 family. Members of this family are mutated in benign familial neonatal seizures, an autosomal dominant syndrome. Moreover, these channels have been found to be practical targets for antiepileptic drug development, perhaps providing a model for studies of other K+ channel subgroups. We conclude with a discussion of directions for future work.

Chapter.  6444 words.  Illustrated.

Subjects: Neurology

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