Chapter

Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy

Nicholas P. Poolos

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0007

Series: Contemporary Neurology Series

Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy

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This chapter describes how the unique biophysical properties of HCN channels lead to an influential role in seizure generation; whether recent evidence truly supports the existence of HCN channelopathy in human epilepsy; and how the mechanisms underlying acquired HCN dysfunction could be targeted by antiepileptic therapies.

Chapter.  7430 words.  Illustrated.

Subjects: Neurology

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