Chapter

Tonic GABA<sub>A</sub> Receptor–Mediated Signaling in Epilepsy

Matthew C. Walker and Dimitri M. Kullmann

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0009

Series: Contemporary Neurology Series

Tonic GABAA Receptor–Mediated Signaling in Epilepsy

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Fast inhibitory signaling in the brain has conventionally been considered to be predominantly mediated by the vesicular release of GABA from presynaptic terminals onto postsynaptic GABAA receptors.1 Transient opening of such receptors results in a brief increase in postsynaptic permeability to Cl, generating an inhibitory postsynaptic potential (IPSP) that reduces the probability of firing of the neuron. However, there is abundant evidence that GABA can also act relatively far from its site of release, and this, together with several other discoveries in the last two decades, has contributed to a reappraisal of the roles of GABAA receptors in modulating neuronal and circuit excitability.1

Chapter.  6548 words.  Illustrated.

Subjects: Neurology

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