Chapter

GABA<sub>A</sub> Receptor Function in Typical Absence Seizures

Vincenzo Crunelli, Nathalie Leresche and David W. Cope

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0018

Series: Contemporary Neurology Series

GABAA Receptor Function in Typical Absence Seizures

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A typical absence is a nonconvulsive epileptic seizure that is characterized by a sudden and relatively brief impairment of consciousness, occurring concomitantly with a generalized, bilaterally synchronous spike (or polyspike) and slow wave discharge (SWD) at 2.5–4 Hz in the electroencephalogram (EEG).1,2 Typical absence seizures are part of the multifaceted clinical and EEG presentation of many idiopathic generalized epilepsies (IGEs), but in childhood absence epilepsy (CAE) these seizures are the only neurological symptom and are not accompanied by either metabolic, neuropathological, or other neurological deficits.1,2 The human studies reviewed in this chapter, therefore, will be those that relate to CAE, since this is the only IGE in which a putative causal link can be made between a typical absence seizure and the underlying genetic variants or pathophysiological mechanisms without the confounding effects of other epileptic and nonepileptic neurological phenotypes.

Chapter.  7530 words.  Illustrated.

Subjects: Neurology

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