On the Basic Mechanisms of Infantile Spasms

John W. Swann and Solomon L. Moshe

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI:

Series: Contemporary Neurology Series

On the Basic Mechanisms of Infantile Spasms

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We are at a very early stage in studying the basic mechanisms of infantile spasms. However, features of several promising animal models have been described, and more may be forthcoming in the near future. Technical challenges are substantial in studying seizures in infant rodents, but they are not insurmountable. The basic science and clinical communities need to evaluate each of the proposed animal models and develop minimal criteria for what they consider to be a valid animal model of this disorder. Once validated, models should provide an unprecedented opportunity to study the mechanisms responsible for this catastrophic epilepsy and hopefully provide new avenues for effective therapies.

Chapter.  8358 words.  Illustrated.

Subjects: Neurology

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