Chapter

Fast Oscillations and Synchronization Examined with In Vitro Models of Epileptogenesis

Roger D. Traub, Miles A. Whittington and Mark O. Cunningham

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0022

Series: Contemporary Neurology Series

Fast Oscillations and Synchronization Examined with In Vitro Models of Epileptogenesis

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For many years, interictal spikes, recorded in a patient's electroencephalogram (EEG), were considered to be a primary indicator that the patient might indeed have epilepsy and that the patient's seizures (when they occurred) were likely to begin in the vicinity of the interictal spike generator. That interictal spikes could often be recorded at the scalp, without the necessity of invasive recording procedures, contributed to their clinical usefulness. A question of continuing importance to basic epilepsy research was naturally this: what factors determine whether “epileptogenic tissue” will produce interictal spikes,1 unequivocal seizure activity, or something intermediate?

Chapter.  5850 words.  Illustrated.

Subjects: Neurology

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