Chapter

Computer Modeling of Epilepsy

Marianne J. Case, Robert J. Morgan, Calvin J. Schneider and Ivan Soltesz

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0023

Series: Contemporary Neurology Series

Computer Modeling of Epilepsy

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There are 50 million people worldwide afflicted with epilepsy, and for roughly 15 million of them, existing epilepsy treatments are not sufficient.1 Such stark facts spur clinicians and researchers to consider dramatically different approaches to treatment, such as an implantable device that could characterize electrical activity in real time, immediately detect when the brain reaches a preictal state, and apply a counteracting current waveform, averting the seizure before it starts (see the next section),2 or an individualized, detailed model of the patient's brain—complete with patient-specific details such as genetic mutations or head trauma—to which doctors could administer virtual drugs to determine the best treatment regimen for that person. Such a tool would complement existing therapies by reducing the likelihood of patients being subjected to treatments to which they are unresponsive.

Chapter.  8090 words.  Illustrated.

Subjects: Neurology

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