Chapter

Head Trauma and Epilepsy

Asla Pitkänen and Tamuna Bolkvadze

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0025

Series: Contemporary Neurology Series

Head Trauma and Epilepsy

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Recent advances in model development provide a platform for studies that are aimed at understanding the post-TBI molecular and cellular alterations leading to epilepsy. Undoubtedly, the search for surrogate markers that identify subjects with the highest risk for posttraumatic epileptogenesis will benefit from novel possibilities for following candidate epileptogenic changes in neuronal circuits in vivo using structural and functional imaging. Some proof-of-principle trials already suggest that post-TBI seizure susceptibility can be favourably modified.

Chapter.  6043 words.  Illustrated.

Subjects: Neurology

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