Chapter

Cell Death and Survival Mechanisms after Single and Repeated Brief Seizures

David C. Henshall and Brian S. Meldrum

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0028

Series: Contemporary Neurology Series

Cell Death and Survival Mechanisms after Single and Repeated Brief Seizures

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Brief seizures can cause neuronal death in animal models. There is emerging evidence that apoptosis-associated signaling pathways are activated by these seizures, but so far we only have proof that these contribute to cell death in models of status epilepticus. There is little evidence that spontaneous seizures in epileptic animals cause acute cell death, but these animals nevertheless display alterations in apoptosis-associated pathways. In humans, there is evidence that recurrent seizures cause subtle or diffuse neuron loss in affected structures. Histopathological analyses have found a molecular signature of apoptosis-associated signaling in resected neocortical and hippocampal material from pharmocoresistant TLE patients.

Chapter.  9084 words.  Illustrated.

Subjects: Neurology

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