Chapter

Histopathology of Human Epilepsy

Nihal C. de Lanerolle, Tih-Shih Lee and Dennis D. Spencer

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0030

Series: Contemporary Neurology Series

Histopathology of Human Epilepsy

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Histopathological lesions that are associated with seizures are described in several neurological disease states. Such histopathological lesions are found in developmental disorders, neoplasms, microbial diseases, cerebrovascular diseases, trauma, and immune-mediated disorders, as well as in disorders primarily related to seizures such as temporal lobe epilepsy (TLE). General descriptions of these lesions have been the subject of several reviews.1,2 Temporal lobe epilepsy, a major seizure disorder that affects over 40 million people worldwide, has received the most study in relation to its histopathology, and the histological lesion is thus best understood in relation to epilepsy. This chapter will review the state of our knowledge in the histopathology of TLE.

Chapter.  11444 words.  Illustrated.

Subjects: Neurology

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