Chapter

The Time Course and Circuit Mechanisms of Acquired Epileptogenesis

F. Edward Dudek and Kevin J. Staley

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0031

Series: Contemporary Neurology Series

The Time Course and Circuit Mechanisms of Acquired Epileptogenesis

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In order to develop and test possible therapeutic strategies for preventing or suppressing epileptogenesis, the temporal features of acquired epilepsy and its underlying mechanisms must be understood. These temporal features include the frequency, duration, and cortical extent of spontaneous seizures; this review focuses primarily on seizure frequency. Traumatic brain injury, stroke, status epilepticus, and infection/inflammation are some of the major causes of acquired epilepsy. The spontaneous recurrent epileptic seizures of acquired epilepsy usually occur after a latent period following the injury, and in at least some patients, the epilepsy is progressive (i.e., the seizures become more frequent and severe). Nearly all patients receive antiepileptic drugs (AEDs) after one or a few clinical seizures. Therefore, quantitative analyses of the temporal features of acquired epileptogenesis, independent of the effects of AEDs, cannot be studied in humans. Animal models of acquired epilepsy can circumvent this problem. The research summarized here analyzed the development of spontaneous recurrent seizures (1) in kainate-treated rats,1 an animal model of temporal lobe epilepsy, and (2) in rats subjected to hypoxic-ischemic brain damage at postnatal day 7, a model of perinatal stroke.2–4

Chapter.  5714 words.  Illustrated.

Subjects: Neurology

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