Chapter

Alterations in Synaptic Function in Epilepsy

Christophe Bernard

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0035

Series: Contemporary Neurology Series

Alterations in Synaptic Function in Epilepsy

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How do alterations in synaptic function relate to seizures and their comorbidities? This question has been particularly difficult to address since epilepsy is often a time-dependent disorder, involving (for example) an initial insult (which may involve genetic alterations, meningitis, brain trauma, etc.) and the subsequent trigger of a number of network modifications. Ultimately, some of these modifications may be directly linked to seizure generation and/or comorbidities. It is therefore important to understand the time course of these changes. This issue has been extensively investigated in experimental models of temporal lobe epilepsy, which are characterized by a latent seizure-free period of about 2 weeks following the initial insult (usually a period of status epilepticus). We will use these models to describe synaptic remodeling and its possible functional consequences in the adult brain, focusing on the hippocampus.

Chapter.  8122 words.  Illustrated.

Subjects: Neurology

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