Chapter

Temporal Lobe Epilepsy and the BDNF Receptor, TrkB

James O. McNamara and Helen E. Scharfman

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0039

Series: Contemporary Neurology Series

Temporal Lobe Epilepsy and the BDNF Receptor, TrkB

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Actions of estrogen and progesterone have been used to explain the changes in seizure frequency or severity in women with catamenial epilepsy. An alternative hypothesis is that BDNF is responsible, because estrogen causes an increase in BDNF expression that can have both acute effects on excitability and delayed, indirect effects by changing GABAergic transmission and GABAA receptors. Allopregnanolone may hold many of the excitatory effects in check during the luteal phase, but two phases of the cycle may be unprotected, the periovulatory and perimenstrual phases. This hypothesis helps explain why progesterone therapy may not always be efficacious in catamenial epilepsy and suggests that control of BDNF would be a logical complementary strategy.

Chapter.  12262 words.  Illustrated.

Subjects: Neurology

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