Chapter

Alterations in the Distribution of GABA<sub>A</sub> Receptors in Epilepsy

Carolyn R. Houser, Nianhui Zhang and Zechun Peng

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0040

Series: Contemporary Neurology Series

Alterations in the Distribution of GABAA Receptors in Epilepsy

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Changes in gamma-aminobutyric acid A receptors (GABAAR) in epilepsy are particularly complex and intriguing because of the multiple subunits that can be altered. The numerous GABAAR subunits (α1–6, β1–3, γ1–3, δ, ε, θ, π, and ρ1–3) typically form heteropentameric receptors that are generally composed of two α, two β, and either one γ, δ, or other more minor subunit. The different subunit combinations create a diversity of receptor subtypes that differ in their function, pharmacology, and regional and cellular localization (see refs. 1 and 2 for reviews). Such diversity provides challenges for understanding the functional effects of GABAAR subunit alterations in epilepsy, but it may also offer unique possibilities for treatment of this disorder.

Chapter.  7574 words.  Illustrated.

Subjects: Neurology

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