Plasticity of GABA<sub>A</sub> Receptors Relevant to Neurosteroid Actions

Istvan Mody

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI:

Series: Contemporary Neurology Series

Plasticity of GABAA Receptors Relevant to Neurosteroid Actions

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It is now widely accepted that phasic (synaptic) and tonic (extrasynaptic) GABAergic influences on neuronal excitability are mediated by different receptors with different pharmacological profiles. This chapter will focus on the plasticity of the neurosteriod-sensitive δ subunit containing gamma-aminobutyric acid A (GABAA) receptors (δ-GABAARs) in animal models of temporal lobe epilepsies (TLE) and its possible consequences for modulating the excitability of the dentate gyrus.

Chapter.  4655 words. 

Subjects: Neurology

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