Chapter

Regulation of GABA<sub>A</sub> Receptor Gene Expression and Epilepsy

Amy R. Brooks-Kayal and Shelley J. Russek

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0044

Series: Contemporary Neurology Series

Regulation of GABAA Receptor Gene Expression and Epilepsy

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Results of research in animal models as well as from human retrospective studies suggest that an initial precipitating event such as status epilepticus (SE), stroke, or traumatic brain injury can increase the risk of later development of the recurrent spontaneous seizures that define epilepsy. The process by which a normal brain transforms into one capable of producing recurrent spontaneous seizures, known as epileptogenesis, is likely to be complex and multifactorial. Among the many changes that occur during epileptogenesis are alterations in expression of a wide variety of genes. Determining what molecular pathways regulate these changes in gene expression, and which of them are consequential or causative of disease, are two of the major challenges of research in this area, and are critical to effectively utilizing this information to develop new therapies for the prevention and treatment of epilepsy.

Chapter.  4575 words.  Illustrated.

Subjects: Neurology

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