Glia–Neuron Interactions

Giuseppe Biagini, Carla Marinelli, Gabriella Panuccio, Giulia Puia and Massimo Avoli

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI:

Series: Contemporary Neurology Series

Glia–Neuron Interactions

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Overall, the evidence reviewed in this chapter indicates a complex interaction between glia and neurons in postlesional epilepsies, depicting a scenario similar to that found when analyzing the role of glial cells in the recovery from brain damage. Indeed, astrocytes may exert both pro-epileptogenic and anti-epileptogenic roles through (1) indirect modulation of neuronal function via release of inflammatory cytokines and neurosteroids, or by altering neurotransmitter release, and (2) by directly influencing neuronal activity via release of gliotransmitters.

Chapter.  6936 words.  Illustrated.

Subjects: Neurology

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