Chapter

Strategies for Studying the Epilepsy Genome

Thomas N. Ferraro, Dennis J. Dlugos, Hakon Hakonarson and Russell J. Buono

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0051

Series: Contemporary Neurology Series

Strategies for Studying the Epilepsy Genome

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Current leading theories on the etiology of the group of diseases called epilepsy implicate both genes and factors in the environment. Genetic research has the potential to identify molecular and cellular mechanisms that can be targeted directly for therapeutic intervention. Although nearly two decades have passed since the discovery of the first epilepsy-causing gene mutation1 and mutations in about a dozen other human genes are now well characterized,2,3 the vast majority of genetic variation that contributes to the development of epilepsy is undiscovered. Thus, there is a critical need to continue to elucidate the epilepsy genome. This chapter will review the comprehensive genome-wide approaches that are being used to achieve this goal.

Chapter.  7706 words. 

Subjects: Neurology

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