Sodium Channel Mutations and Epilepsy

William A. Catterall

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI:

Series: Contemporary Neurology Series

Sodium Channel Mutations and Epilepsy

Show Summary Details


While many pathophysiological changes contribute to seizure susceptibility, recent work suggests that genetic factors are especially important. Polygenic inheritance patterns have been associated with febrile seizures and idiopathic epilepsy and may be important in determining susceptibility to acquired epilepsy following brain injury. Monogenic inheritance patterns are seen in a number of epilepsies associated with mutations in ligand-gated or voltage-gated ion channels. The genes most frequently associated with epilepsy encode brain sodium channels.

Chapter.  7706 words.  Illustrated.

Subjects: Neurology

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.