Chapter

Sodium Channel Mutations and Epilepsy

William A. Catterall

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0052

Series: Contemporary Neurology Series

Sodium Channel Mutations and Epilepsy

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While many pathophysiological changes contribute to seizure susceptibility, recent work suggests that genetic factors are especially important. Polygenic inheritance patterns have been associated with febrile seizures and idiopathic epilepsy and may be important in determining susceptibility to acquired epilepsy following brain injury. Monogenic inheritance patterns are seen in a number of epilepsies associated with mutations in ligand-gated or voltage-gated ion channels. The genes most frequently associated with epilepsy encode brain sodium channels.

Chapter.  7706 words.  Illustrated.

Subjects: Neurology

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