Pathophysiology of Epilepsy in Autism Spectrum Disorders

Carl E. Stafstrom, Paul J. Hagerman and Isaac N. Pessah

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI:

Series: Contemporary Neurology Series

Pathophysiology of Epilepsy in Autism Spectrum Disorders

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Why are seizures so common in children with autism? This relatively straightforward question does not, unfortunately, have a straightforward answer. In this chapter, we explore this question from clinical, pathophysiological, and molecular perspectives, using as examples two genetic disorders that share a high prevalence of autism and epilepsy—fragile X syndrome (FXS) and tuberous sclerosis complex (TSC)—with the hope that understanding the pathophysiology of these monogenic conditions will lead to broader understanding of neural hyperexcitability in other autism syndromes. We conclude by discussing cellular and network dysfunctions that might be amenable to targeted treatments in these disorders, with potential wider applicability to idiopathic autism.

Chapter.  9094 words.  Illustrated.

Subjects: Neurology

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