Chapter

Deep Brain Stimulation for Epilepsy

Kevin D. Graber and Robert S. Fisher

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0079

Series: Contemporary Neurology Series

Deep Brain Stimulation for Epilepsy

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Studies of deep brain stimulation in laboratory models of seizures and epilepsy are invaluable for understanding the mechanisms of stimulation and for identifying the best targets and parameters of stimulation. Unfortunately, existing laboratory studies of brain stimulation in epilepsy models present an incomplete and often contradictory picture (Table 79–1). Some efficacy for deep brain stimulation has been documented in labora tory models involving the cerebellar cortex, caudate, hypothalamus, subthalamus, centromedian and midline thalamus, anterior thalamus, hippocampus, and neocortex. However, many studies are empiric in nature and mechanisms, and our understanding of the optimal parameters remains incomplete. Pivotal clinical trials with the ANT and responsive neural stimulation of the hippocampus and neocortex have been effective in reducing seizures. These recent successes in clinical studies may give more impetus to laboratory investigations, which in turn will potentially further our clinical practice.

Chapter.  10037 words.  Illustrated.

Subjects: Neurology

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