Chapter

Animal Models for Evaluating Antiepileptogenesis

H. Steve White

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0080

Series: Contemporary Neurology Series

Animal Models for Evaluating Antiepileptogenesis

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The need to find a therapy that will prevent or delay the development of epilepsy in the susceptible individual is evident, and many of the required tools have already been developed. Nonetheless, there are many practical challenges and hurdles at both the preclinical and clinical levels that must be overcome before a cure can be developed. Prior to embarking on a clinical trial, there should be some evidence that a hypothetical therapy is effective in one or more animal models of epileptogenesis. However, unlike the animal models routinely employed in the search for novel anticonvulsant compounds, the animal models of epileptogenesis that are currently available have not been validated clinically. Unfortunately, clinical validation will not be provided until the first truly antiepileptic or disease-modifying therapy has been found to be effective in an appropriately designed clinical trial. With this in mind, it is still unknown what preclinical evidence of efficacy would be required before one would be willing to embark on an expensive clinical trial that involves a path not yet paved by past experience. Nevertheless, the scientific community should not be discouraged from pursing this approach but should clearly be aware of the limitations of the existing models and employ caution when designing preclinical studies and interpreting the results obtained.

Chapter.  8823 words.  Illustrated.

Subjects: Neurology

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