Strategies for Antiepileptogenesis

Wolfgang Löscher

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI:

Series: Contemporary Neurology Series

Strategies for Antiepileptogenesis

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Epileptogenesis, that is, the process leading to epilepsy, is a common sequel of brain insults such as head trauma, cerebrovascular disease, brain tumors, neurosurgical procedures, neurodegenerative conditions, status epilepticus (SE), and complex febrile seizures.1–3 Following such brain insults, there is a cascade of morphological and functional changes in the injured area over months to years before the occurrence of spontaneous recurrent seizures, that is, the hallmark of epilepsy (Fig. 81–1). This latent (“silent”) period may offer a therapeutic window for the prevention of epileptogenesis and the subsequent development of unprovoked seizures and epilepsy.2

Chapter.  5750 words.  Illustrated.

Subjects: Neurology

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