Chapter

Drug Resistance

Jan A. Gorter and Heidrun Potschka

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0084

Series: Contemporary Neurology Series

Drug Resistance

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Despite the ongoing development of novel AEDs, drug resistance remains a major problem in the clinical management of epilepsy patients. Thus, strategies to break new grounds in the development of novel AEDs or alternative therapeutic approaches are urgently needed. Based on epidemiological data as well as experimental studies, several hypotheses have been proposed to explain the phenomenon of drug resistance. These hypotheses suggest specific implications for future drug development and clinical therapeutic management. However, clinical evidence for the drug resistance mechanisms is still limited. Therefore, novel tools to study putative resistance mechanisms in individual patients are needed. New techniques might also guide individualized therapeutic decisions in the future.

Chapter.  7140 words.  Illustrated.

Subjects: Neurology

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