Chapter

Neural Stem Cell Therapy for Temporal Lobe Epilepsy

Ashok K. Shetty

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0085

Series: Contemporary Neurology Series

Neural Stem Cell Therapy for Temporal Lobe Epilepsy

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The major objective of this chapter is to evaluate the contemporary knowledge and to put forward perspectives concerning the NSC grafting therapy for TLE. Since the efficiency of grafting of neural progenitors obtained from the fetal brain or ES cells are covered in other chapters in this book, this chapter is deliberately confined to studies on the efficacy of NSC grafts in TLE prototypes. The first section will focus on the prospects for preventing or minimizing SRS using NSC grafting procedures that are performed shortly after the initial precipitating injury (IPI), such as SE or a direct excitotoxic lesion. The second section will consider the promise of NSC grafting therapy for restraining seizures and easing cognitive dysfunction when applied shortly after or at prolonged periods after the onset of SE- or kindling- induced TLE. Several critical issues that need to be resolved before initiating the clinical application of NSC grafting therapy for TLE are also discussed.

Chapter.  7335 words.  Illustrated.

Subjects: Neurology

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