Chapter

Embryonic Stem Cell Therapy for Intractable Epilepsy

Janice R. Naegele, Mohan C. Vemuri and Lorenz Studer

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0086

Series: Contemporary Neurology Series

Embryonic Stem Cell Therapy for Intractable Epilepsy

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Envisioning a world in which humans are able to regenerate severed limbs, rewire neural pathways, and enhance sensory perception has been a mainstay of science fiction novels and movies for decades. While human limb regeneration is still not possible, remarkable developments in the fields of stem cell biology and neuroscience are leading the way for stem cell-based therapies to amend brain and spinal cord damage and repair sensory organs. In this chapter, we discuss recent efforts to derive neural stem cells from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) and their applications to treating conditions such as temporal lobe epilepsy (TLE) and neurodegenerative diseases.

Chapter.  7251 words.  Illustrated.

Subjects: Neurology

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