Chapter

Reversing Disorders of Neuronal Migration and Differentiation in Animal Models

Jean-Bernard Manent and Joseph J. LoTurco

in Jasper's Basic Mechanisms of the Epilepsies

Fourth edition

Published on behalf of ©Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Richard W. Olsen, and Antonio V. Delgado-Escueta

Published in print July 2012 | ISBN: 9780199746545
Published online April 2013 | e-ISBN: 9780199322817 | DOI: http://dx.doi.org/10.1093/med/9780199746545.003.0088

Series: Contemporary Neurology Series

Reversing Disorders of Neuronal Migration and Differentiation in Animal Models

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In this chapter, we review results from animal models that begin to provide evidence that genetically based developmental abnormalities leading to epilepsy can be reversed by reactivating developmental programs. The abnormalities reversed include disruptions in neuronal migration and differentiation. Moreover, molecular genetic and pharmacological interventions in animal models have been shown to reduce morphological disruptions, seizures, and associated behavioral impairments. Significant challenges remain, particularly with respect to translating the approaches used in animal models into viable human therapies. However, the diversity of both the methods used and the disruptions successfully targeted to date should encourage future research and therapy development in this area.

Chapter.  5948 words.  Illustrated.

Subjects: Neurology

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