Brainstem and Cerebellum

Robert B. Darnell and Jerome B. Posner

in Paraneoplastic Syndromes

Published on behalf of Oxford University Press

Published in print April 2010 | ISBN: 9780199772735
Published online April 2013 | e-ISBN: 9780199322916 | DOI:

Series: Contemporary Neurology Series

Brainstem and Cerebellum

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This chapter concerns paraneoplastic lesions that cause dysfunction of central nervous system (CNS) structures between the tentorium cerebelli and the foramen magnum, (i.e., the posterior fossa). The two major structures in that compartment are the brainstem (midbrain, pons and medulla) and the cerebellum. When the brainstem is affected by a paraneoplastic syndrome, the disorder is usually part of a more widespread encephalomyelitis (see Chapter 4). With the exception of paraneoplastic opsoclonus, it is quite unusual for the brainstem to be involved in isolation and even more unusual for brainstem dysfunction to cause a single symptom. On the other hand, paraneoplastic cerebellar degeneration (PCD) frequently occurs as an isolated event causing nystagmus, dysarthria, and appendicular and gait ataxia without other signs of neurologic dysfunction.

Chapter.  19707 words.  Illustrated.

Subjects: Neurology

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