Non-Neurologic Paraneoplastic Syndromes

Robert B. Darnell and Jerome B. Posner

in Paraneoplastic Syndromes

Published on behalf of Oxford University Press

Published in print April 2010 | ISBN: 9780199772735
Published online April 2013 | e-ISBN: 9780199322916 | DOI:

Series: Contemporary Neurology Series

Non-Neurologic Paraneoplastic Syndromes

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This chapter describes some of the paraneoplastic syndromes that affect organs or tissues other than the nervous system (Table 10–1). These disorders are included for several reasons. (1) Although they do not involve the nervous system directly, they often cause nervous system symptoms. An example is Cushing syndrome, caused by ectopic adrenocorticotropin hormone (ACTH) secretion. This disorder can cause both central nervous system (CNS) symptoms and neuromuscular symptoms (see later discussion). (2) The disorders can be confused with a neurologic paraneoplastic syndrome. Other examples include osteonecrosis of the hip—in our experience, often confused with femoral neuropathy and rheumatologic disorders causing pain that is sometimes confused with paraneoplastic neuropathy. (3) Some of these so-called nonneurologic paraneoplastic syndromes cause considerable pain; we consider that pain to be a neurologic symptom. (4) As with the paraneoplastic neurologic disorders described in the preceding chapters, these disorders should alert the clinician to a possible occult cancer.

Chapter.  16875 words.  Illustrated.

Subjects: Neurology

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